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RUNX-2 (N278) polyclonal antibody

货号: BS2831

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2831

Product Name :RUNX-2 (N278) polyclonal antibody

Swiss-Prot :Q13950

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :RUNX2 (Runt-related transcription Factor) is a transcription factor that binds to its canonical consensus sequence 5’- PYGPYGGT-3’ in a number of promoters and enhancers. They include LCK, T-cell receptor enhancers, and various bone related genes such as osteocalcin, osteopontin, and bone sialoprotein. As a result of this, RUNX2 is involved in osteoblastic differentiation and skeletal morphogenesis. RUNX2 contains a proline/serine/ threonine-rich region at its C-terminus that has shown to be critical for its transcriptional activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RUNX2 (N278) polyclonal antibody detects endogenous levels of RUNX2 protein.

BiowMW :~ 57 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ESC Pluripotency and Differentiation Signaling Pathway,

Alternative Name :Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; RUNX2; AML3; CBFA1; OSF2; PEBP2A

Immunogen :Synthetic peptide, corresponding to amino acids 246-297 of Human RUNX-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RUNX-2 (N278) polyclonal antibody at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate(40ug) Lane2:Jurkat whole cell lysate(40ug) Lane3:SP2/0 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug)

Twist-related protein 1 negatively regulated osteoblastic transdifferentiation of human aortic valve interstitial cells by directly inhibiting runt-related transcription factor 2

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ApplicationIHC

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SpeciesHuman

PMID24703637
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IF3.216

SpeciesMouse

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Local delivery of COMP-angiopoietin 1 accelerates new bone formation in rat calvarial defects

JournalJournal Of Biomedical Materials Research Part A

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Overexpression of COMP-Angiopoietin-1 in K14-Expressing Cells Impairs Hematopoiesis and Disturbs Erythrocyte Maturation

JournalMolecules And Cells

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IF5.034

SpeciesMouse

PMID33935045
Spatiotemporal characterization of microdamage accumulation and its targeted remodeling mechanisms in diabetic fatigued bone

JournalFaseb Journal

ApplicationIHC

IF4.966

SpeciesRat

PMID31908007