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CXCR-4 (V340) polyclonal antibody

货号: BS2771

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2771

Product Name :CXCR-4 (V340) polyclonal antibody

Swiss-Prot :P61073

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :The C-X-C or α chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (variously referred to as LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major coreceptor for T-tropic HIV-1 and SDF-1 has been shown to inhibit HIV-1 infection.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CXCR-4 (V340) polyclonal antibody detects endogenous levels of CXCR-4 protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven; transmembrane domain receptor; LESTR; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD184; CXCR4

Immunogen :Synthetic peptide, corresponding to amino acids 310-360 of Human CXCR-4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CXCR-4 (V340) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate

Transforming growth factor‑β1 in the microenvironment of ischemia reperfusion‑injured kidney enhances the chemotaxis of mesenchymal stem cells to stromal cell‑derived factor‑1 through upregulation of surface chemokine (C‑X‑C motif) receptor 4

JournalMolecular Medicine Reports

ApplicationWB

IF2.952

SpeciesRat

PMID24573381
Resveratrol inhibits hepatocellular carcinoma progression driven by hepatic stellate cells by targeting Gli-1

JournalMolecular And Cellular Biochemistry

ApplicationWB

IF3.396

SpeciesHuman

PMID
Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages

JournalCell Death & Disease

ApplicationWB

IF5.959

SpeciesHuman

PMID29500439
Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment

JournalAnnals of Translational Medicine

ApplicationIHC,WB

IF3.297

SpeciesMouse,Human

PMID33145265