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PTH/PTHrP-R (L187) polyclonal antibody（KU）

货号: BS2710

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2710

Product Name :PTH/PTHrP-R (L187) polyclonal antibody（KU）

Swiss-Prot :Q03431

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Parathyroid hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by raising blood levels of calcium through various mechanisms. PTH stimulates bone formation to increase bone mass and strength in rats and humans. Within the PTH molecule, the essential activity is associated with the first 34 amino acids at the amino-terminus of the molecule. The gene encoding PTH maps to human chromosome 11p15.3-p15.1. Parathyroid hormone-related protein (PTH-rP) is an autocrine factor that is structurally related to PTH yet, unlike PTH, which is synthesized only by the parathyroid cells, PTH-rP is synthesized by several cell types. PTH-rP regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Isolated from the culture medium of a human lung cancer cell line, PTH-rP produces PTH-like effects that are characterized as humoral hypercalcemia of malignancy.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PTH/PTHrP-R (L187) polyclonal antibody detects endogenous levels of PTH/PTHrP-R protein.

BiowMW :~ 52, 66kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTH1R; PTHR; PTHR1

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human PTH.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PTH/PTHrP-R (L187) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:The Kidney tissue lysate of Rat(40ug) Lane3:The Kidney tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of PTH /PTHrP-R (L187) pAb in paraffin-embedded human brain muscle tissue.

Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma

JournalJournal Of Experimental & Clinical Cancer Research

ApplicationIHC,WB

IF5.646

SpeciesHuman

PMID25539663
PTHLH Predicts the Prognosis of Patients with Oral Leukoplakia

JournalOncoTargets and Therapy

ApplicationIHC

IF3.337

SpeciesHuman

PMID33116586