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IRF-4 (Y294) polyclonal antibody

货号: BS2659

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS2659

Product Name :IRF-4 (Y294) polyclonal antibody

Swiss-Prot :Q15306

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC IF

Application_all :IHC: 1:50~1:200 IF: 1:50~1:200

Background :Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRF-4 (Y294) polyclonal antibody detects endogenous levels of IRF-4 protein.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5; IRF4; MUM1

Immunogen :Synthetic peptide, corresponding to amino acids 262-318 of Human IRF-4.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of IRF-4 (Y294) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.showing nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2–IRF pathway

JournalINFLAMMOPHARMACOLOGY

ApplicationWB,IF

IF4.473

SpeciesMouse

PMID35235107
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension

JournalJOURNAL OF HYPERTENSION

ApplicationIHC

IF4.776

SpeciesMouse

PMID36883469
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension

JournalHYPERTENSION RESEARCH

ApplicationIHC

IF5.528

SpeciesMouse

PMID37248323