Product Name :Dok-2 (R293) polyclonal antibody
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Dok-2 (R293) polyclonal antibody detects endogenous levels of Dok-2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2); DOK2
Immunogen :Synthetic peptide, corresponding to amino acids 271-320 of Human Dok-2.
Modification :Unmodification
