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CRF-RI (H177) polyclonal antibody（KU）

货号: BS2590

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2590

Product Name :CRF-RI (H177) polyclonal antibody（KU）

Swiss-Prot :P34998

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :A high affinity CRF binding protein, designated CRF-BP, has been discovered in postmortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of “free CRF” available to bind CRFRs. Two CRF receptors, designated CRF-RI and CFR-RII, exhibit distinct brain localizations.Two forms of CFR-RII, designated CFR-RIIα and CFR-RIIβ, result from alternative mRNA splicing. Urocortin, an additional member of the CRF family, shares 63% sequence identity with urotensin and 45% sequence identity with CRF. Urocortin specifically binds to and activates CRF-RI and CRF-RII, but binds to CRF-RII more efficiently than CRF, suggesting that it may be the true, high affinity ligand for the CRF receptor type II.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CRF-RI (H177) polyclonal antibody detects endogenous levels of CRF-RI protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1; CRHR1; CRFR; CRFR1; CRHR

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human CRF-RI.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CRF-RI (H177) pAb at 1:1000 dilution Lane1:L02 whole cell lysate(20ug) Lane2:MCF-7 whole cell lysate(20ug) Lane3:A549 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug) Lane5:BV2 whole cell lysate(40ug)

Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation

JournalEnvironmental Health and Preventive Medicine

ApplicationWB

IF3.674

SpeciesRat

PMID29228900
Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid

JournalJournal Of Alzheimers Disease

ApplicationWB

IF3.517

SpeciesMouse

PMID26577520
Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex

JournalJournal Of The Neurological Sciences

ApplicationWB

IF2.651

SpeciesRat

PMID27538655
CRH/CRHR1 mediates prenatal synthetic glucocorticoid programming of depression-like behavior across 2 generations

JournalFaseb Journal

ApplicationWB

IF5.391

SpeciesRat

PMID