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TWEAK (P73) polyclonal antibody（KU）

货号: BS2454

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2454

Product Name :TWEAK (P73) polyclonal antibody（KU）

Swiss-Prot :O43508

Host :Rabbit

Reactivity :Human

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placenta, lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TWEAK (P73) polyclonal antibody detects endogenous levels of TWEAK protein.

BiowMW :~ 27 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; TNFSF12; APO3L; DR3LG; UNQ181/PRO207

Immunogen :Synthetic peptide, corresponding to amino acids 51-100 of Human TWEAK.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TWEAK (P73) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:A2780 whole cell lysate(40ug) Lane5:SP2/0 whole cell lysate(40ug) Lane6:C6 whole cell lysate(40ug) Lane7:PC12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of TWEAK (P73) pAb in paraffin-embedded human colon carcinoma tissue at 1:50.showing secreted and cell membrane staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.