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WWOX (A7) polyclonal antibody（KU）

货号: BS2426

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2426

Product Name :WWOX (A7) polyclonal antibody（KU）

Swiss-Prot :Q9NZC7

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :WWOX (WW domain containing oxidoreductase) protein is a candidate tumor suppressor consisting of two WW domains that influence protein-protein interactions, and a short chain dehydrogenase (SDR) domain, that influences sex-steroid metabolism. Modulation of the WWOX gene influences esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines MDA-MB-435 and T47D. The murine homolog WOX1 localizes in the mitochondria, and contains a mitochondrial targeting sequence mapping within the SDR domain. JNK1 can physically associate with WOX1 and sequester WOX1-dependent apoptosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :WWOX (A7) polyclonal antibody detects endogenous levels of WWOX protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase; WWOX; FOR; WOX1

Immunogen :Synthetic peptide, corresponding to the N-terminual of Human WWOX.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of WWOX (A7) polyclonal antibody at 1:500 dilution Lane1:The Testis tissue lysate of Mouse(40ug) Lane2:The Testis tissue lysate of Rat(40ug) Lane3:SK-OVCAR3 whole cell lysate(40ug) Lane4:A2780 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of WWOX (A7) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of WWOX (A7) pAb in paraffin-embedded human colon carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of WWOX (A7) pAb in paraffin-embedded human liver carcinoma tissue at 1:50.showing cytoplasmic and nucleus staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.