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SR-4 (D47) polyclonal antibody（KU）

货号: BS2390

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2390

Product Name :SR-4 (D47) polyclonal antibody（KU）

Swiss-Prot :Q13639

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. The gene which encodes SR-3 maps to human chromosome 11q23.1-q23.2. SR-4 mediates widespread effects in central and peripheral nervous systems. The gene which encodes SR-4 maps to human chromosome 5q31-q33. SR-7 belongs to the superfamily of G protein-coupled receptors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SR-4 (D47) polyclonal antibody detects endogenous levels of SR-4 protein.

BiowMW :~ 48 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4; HTR4

Immunogen :Synthetic peptide, corresponding to amino acids 14-66 of Human SR-4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SR-4 (D47) pAb at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:K562 whole cell lysate(40ug) Lane5:U-87MG whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of SR-4 (D47) pAb in paraffin-embedded human brain tissue.