产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

MARK1/2/3/4 (G152) polyclonal antibody（KU）

货号: BS2369

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2369

Product Name :MARK1/2/3/4 (G152) polyclonal antibody（KU）

Swiss-Prot :Q9P0L2/Q7KZI7/P27448/Q96L34

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases was identified based on their ability to phosphorylate microtubule-associated proteins (MAPs) including tau, MAP2 and MAP4. MARK proteins phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics. In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimer's disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death. The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MARK1/2/3/4 pAb detects endogenous levels of MARK1/2/3/4 protein.

BiowMW :~ 85 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Regulation of Microtubule Dynamics,

Alternative Name :Adhesion G protein-coupled receptor F5; G-protein coupled receptor 116; ADGRF5; GPR116; KIAA0758

Immunogen :Synthetic peptide, corresponding to Human GPR116.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MARK1/2/3/4 (G152) pAb at 1:1000 dilution Lane1:The Brain tissue lysate of Rat(40ug) Lane2:The Heart tissue lysate of Mouse(5ug) Lane3:L02 whole cell lysate(30ug) Lane4:HEK293T whole cell lysate(30ug)