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COPS5 / JAB1 (K191) polyclonal antibody（KU）

货号: BS2340

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2340

Product Name :COPS5 / JAB1 (K191) polyclonal antibody（KU）

Swiss-Prot :Q92905

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :JAB1 (K191) polyclonal antibody detects endogenous levels of JAB1 protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein; COPS5; CSN5; JAB1

Immunogen :Synthetic peptide, corresponding to amino acids 160-212 of Human COPS5 / JAB1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of COPS5/JAB1 (K191) pAb at 1:1000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:The Lung tissue lysate of Rat(40ug) Lane4:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of COPS5 / JAB1 (K191) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.