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Mob1A/B (D127) polyclonal antibody（KU）

货号: BS2322

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2322

Product Name :Mob1A/B (D127) polyclonal antibody（KU）

Swiss-Prot :Q7L9L4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development. There are two MOB1 proteins in humans, MOB1α and MOB1β, that are encoded by two different genes but which have greater than 95% amino acid sequence identity. Both forms bind to members of the nuclear Dbf2-related (NDR) kinases, such as LATS1/2 and NDR1/2, thereby stimulating kinase activity. This binding is promoted by the phosphorylation of MOB1 at several threonine residues by MST1 and/or MST2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mob1A/B (D127) polyclonal antibody detects endogenous levels of Mob1A/B protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :hippo Signaling,

Alternative Name :MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A; MOB1B; MOB4A; MOBKL1A

Immunogen :Synthetic peptide, corresponding to amino acids 97-157 of Human Mob1A/B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Mob1A/B (D127) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:H1792 whole cell lysate(20ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug) Lane5:PMVEC whole cell lysate(40ug)