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Ksr2 (I694) polyclonal antibody（KU）

货号: BS2321

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2321

Product Name :Ksr2 (I694) polyclonal antibody（KU）

Swiss-Prot :Q6VAB6

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Kinase suppressor of Ras (Ksr) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr-1 and Ksr-2. Ksr-2 plays a key role in Ras-mediated signaling during germline meiotic progression and functions redundantly with Ksr-1 during the development of the excretory system pathway, hermaphrodite vulva, and male spicules. Ksr-2 also functions as a negative regulator of the MEKK3-mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NF˚B pathways, and it simultaneously inhibits MEKK3-mediated Il-8 production.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ksr2 (I694) polyclonal antibody detects endogenous levels of Ksr2 protein.

BiowMW :~ 108 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KSR2; Kinase suppressor of Ras 2

Immunogen :Synthetic peptide, corresponding to amino acids 662-724 of Human Ksr2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Ksr2 (I694) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:AML-12 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Ksr2 (I694) pAb in paraffin-embedded human brain tissue. .