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PEBP2β (R33) polyclonal antibody（KU）

货号: BS2307

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2307

Product Name :PEBP2β (R33) polyclonal antibody（KU）

Swiss-Prot :Q13951

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, α and β, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2α subunits, PEBP2αA, PEBP2αB and PEBP2αC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory β subunit, which facilitates DNA binding of the α subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PEBP2β (R33) polyclonal antibody detects endogenous levels of PEBP2β protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Core-binding factor subunit beta; CBF-beta; CBF-β; CBFβ; Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-β; PEA2β; PEA2-beta; PEBP2-β; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; CBFB

Immunogen :Synthetic peptide, corresponding to amino acids 2-56 of Human PEBP2β.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PEBP2β (R33) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:SGC-7901 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of PEBP2β (R33) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.