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TMPRSS3 (F440) polyclonal antibody

货号: BS2289
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS2289
Product Name :TMPRSS3 (F440) polyclonal antibody
Swiss-Prot :P57727
Host :Rabbit
Reactivity :Human,Mouse,Rat
Applications :IHC IF
Application_all :IHC: 1:50~1:200 IF: 1:50~1:200
Background :The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochlea, a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :TMPRSS3 (F440) polyclonal antibody detects endogenous levels of TMPRSS3 protein.
BiowMW :~ 49 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Transmembrane protease serine 3; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein; ECHOS1; TADG12; UNQ323/PRO382
Immunogen :Synthetic peptide, corresponding to amino acids 420-460 of Human TMPRSS3.
Conjugate :Unconjugated
Modification :Unmodification

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com