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PKA Iβ reg (F138) polyclonal antibody（KU）

货号: BS2269

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2269

Product Name :PKA Iβ reg (F138) polyclonal antibody（KU）

Swiss-Prot :P31321

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PKA Iβ reg (F138) polyclonal antibody detects endogenous levels of PKA Iβ reg protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :cAMP-dependent protein kinase type I-beta regulatory subunit; PRKAR1B

Immunogen :Synthetic peptide, corresponding to amino acids 120-160 of Human PKA Iβ reg.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of PKA Iβ reg (F138) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Mouse(10ug) Lane2:The Brain tissue lysate of Rat(20ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:K562 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of PKA Iβ reg (F138) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.