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Rad50 (A708) polyclonal antibody（KU）

货号: BS2232

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2232

Product Name :Rad50 (A708) polyclonal antibody（KU）

Swiss-Prot :Q92878

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54, MRE11) mediate DNA double-strand break repair (DSBR) for DNA damage that otherwise could cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single-stranded DNA ends and catalyzes DNA-DNA interaction necessary for the annealing of complementary strands.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Rad50 (A708) polyclonal antibody detects endogenous levels of Rad50 protein.

BiowMW :~ 170 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA repair protein RAD50; hRAD50; RAD50

Immunogen :Synthetic peptide, corresponding to amino acids 670-722 of Human Rad50.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Rad50 (A708) polyclonal antibody at 1:500 dilution Lane1:786-O whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:SGC-7901 whole cell lysate(40ug) Lane4:SK-OVCAR3 whole cell lysate(40ug) Lane5:The Testis tissue lysate of Mouse(40ug) Lane6:The Testis tissue lysate of Rat(40ug) Lane7:C6 whole cell lysate(40ug)