产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

AR-α1A (Q365) polyclonal antibody（KU）

货号: BS2207

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2207

Product Name :AR-α1A (Q365) polyclonal antibody（KU）

Swiss-Prot :P35348

Host :Rabbit

Reactivity :Human

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :α1A-adrenergic receptors (α1A-ARs) mediate actions in the sympathetic nervous system through the binding of the catecholamines, epinephrine and norepinephrine. α1A-AR couples to Gq/11 and regulates blood pressure due to changes in vascular tone and cardiac output. Alternative splicing of the ADRA1A gene generates four isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation. α1A-AR transcripts are abundant in heart, brain, liver and prostate. α1A-AR transcript sizes of 6.0, 4.0, 3.0, and 2.0 kb have been detected in liver. Transcripts of 6.0, 4.0 and 3.0 kb have been detected in heart, and transcripts of 6.0 and 4.0 kb have been detected in prostate

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AR-α1A (Q365) polyclonal antibody detects endogenous levels of AR-α1A protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; α1A-AR; α-1A AR

Immunogen :Synthetic peptide, corresponding to amino acids 350-400 of Human AR-α1A.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AR-α1A (Q365) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug) Lane3:LO2 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of AR-α1A (Q365) pAb in paraffin-embedded human brain tissue.

Dopamine D1-like receptors regulate the α1A-adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor knockout mice

JournalAmerican Journal Of Physiology-Renal Physiology

ApplicationIP,IMMUNOSTAINING,WB

IF3.377

SpeciesHuman,Mouse

PMID25339698