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CNOT7 (N19) polyclonal antibody（KU）

货号: BS2162

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2162

Product Name :CNOT7 (N19) polyclonal antibody（KU）

Swiss-Prot :Q9UIV1

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :CNOT7 (CCR4-NOT transcription complex, subunit 7), also known as CAF1 (CCR4-associated factor 1), hCAF-1 or BTG1-binding factor 1, is a member of the CAF1 family. Localizing to the nucleus, CNOT7 is ubiquitously expressed and is believed to function as a transcription factor, playing a role in a wide variety of processes. CNOT7 functions as a component of the evolutionarily conserved CCR4-NOT complex, a multi-subunit complex that participates in transcription as well as mRNA degradation. CNOT7 and other subunits of the CCR4-NOT complex play a role in the regulation of nuclear hormone receptor activities. CNOT7 directly binds to and interacts with RXR∫, TOB1, TOB2, BTG1, BTG2 and BTG3. In addition, CNOT7 knockout mice are sterile and show an increase in bone mass, suggesting an important role for CNOT7 in spermatogenesis and as a suppressor of bone mass and BMP (bone morphogenetic protein) actions in osteoblasts.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CNOT7 (N19) polyclonal antibody detects endogenous levels of CNOT7 protein.

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a

Immunogen :Synthetic peptide, corresponding to amino acids 10-54 of Human CNOT7

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CNOT7 (N19) Antibody at 1:1000 dilution Lane1:Myla2059 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:3T3-L1 whole cell lysate(40ug)