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PIG3 (L265) polyclonal antibody

货号: BS2085

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2085

Product Name :PIG3 (L265) polyclonal antibody

Swiss-Prot :Q53FA7

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The PIG (p53-induced gene) gene family encodes redox-controlling proteins that are involved in p53 tumor suppressor activity. One member of the PIG gene family, p53-inducible gene 3 (PIG3), is a p53 responsive gene that maps, in humans, to chromosome 2p and encodes a protein with significant homology to oxidoreductases. Oxidoreductases are enzymes involved in cellular responses to oxidative stress and irradiation, and they influence the involvement of PIG3 in the metabolism of reactive oxygen species. PIG3 is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 is p53 dependent and occurs with delayed kinetics as compared with other p53 downstream targets. PIG3 may act with caspase-8 as a key regulatory element in p53-dependent transcriptional deregulation by triggering the caspase cascade and mitochondrial breakdown. PIG3 is highly up-regulated by p53 and may be useful for detecting transient activation of p53.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PIG3 (L265) polyclonal antibody detects endogenous levels of PIG3 protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein; TP53I3; PIG3

Immunogen :Synthetic peptide, corresponding to amino acids 230-286 of Human PIG3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PIG3 (L265) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate

Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in Tumorigenesis and Metastasis

JournalBMC Medical Genomics

ApplicationWB

IF3.063

SpeciesHuman

PMID
Combination of Patulin and Chlorpyrifos Synergistically Induces Hepatotoxicity via Inhibition of Catalase Activity and Generation of Reactive Oxygen Species

JournalJournal Of Agricultural And Food Chemistry

ApplicationWB

IF4.192

SpeciesMouse

PMID31537057