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SURF-1 (F181) polyclonal antibody

货号: BS2068

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2068

Product Name :SURF-1 (F181) polyclonal antibody

Swiss-Prot :Q15526

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :The SURF-1 protein demonstrates a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. Expressed in the inner mitochondrial membrane, mutations of the SURF-1 gene generally cause cytochrome c oxidase complex IV deficiency. Shortage of complex IV leads to Leigh syndrome, a severe neurological disorder. Leigh syndrome patients are usually subject to rapidly progressive encephalopathy, characterized by necrotic lesions in subcortical brain regions. SURF-1 mutations correlate to high post-implantation embryonic lethality as well as early-onset mortality of post-natal individuals. Considerable deficit in muscle strength and motor performance is also a profound and isolated defect of SURF-1 activity in skeletal muscle and liver. Heart, brain and skeletal muscle morphological abnormalities frequently occur due to SURF-1 mutations.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SURF-1 (F181) polyclonal antibody detects endogenous levels of SURF-1 protein.

BiowMW :~ 33 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Surfeit locus protein 1; SURF1; SURF-1

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human SURF-1.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of SURF-1 (F181) pAb in paraffin-embedded liver cancer tissue at 1:100.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）