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MTA1 (K182) polyclonal antibody（KU）

货号: BS2045

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2045

Product Name :MTA1 (K182) polyclonal antibody（KU）

Swiss-Prot :Q13330

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :MTA1 (metastasis-associated protein 1) is a component of the NURD (for nucleosome remodeling and histone deacetylation) complex, which is associated with ATP-dependent chromatin-remodeling and histone deacetylase activity. MTA1 functions in conjunction with other components of NURD to mediate transcriptional repression as it facilitates the association of repressor molecules with the chromatin. Structurally, MTA1 contains a single SH3-binding motif and a zinc finger domain, along with a region similar to the corepressor protein N-Cor. MTA1 is normally expressed at low levels in various tissues and is more highly expressed in testis. Overexpression of MTA1 correlates with tumor invasion and metastasis in various carcinomas including colorectal, gastrointestinal and breast carcinomas.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MTA1 (K182) polyclonal antibody detects endogenous levels of MTA1 protein.

BiowMW :~ 80 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ATP-Dependent Chromatin Remodeling Complexes,DNA Methylation,

Alternative Name :Metastasis-associated protein MTA1

Immunogen :Synthetic peptide, corresponding to amino acids 153-202 of Human MTA1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MTA1 (K182) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(10ug) Lane2:MCF-7 whole cell lysate(20ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of MTA1 (K182) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.