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CREM (I106) polyclonal antibody

货号: BS2032

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2032

Product Name :CREM (I106) polyclonal antibody

Swiss-Prot :Q03060

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREM, CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. The transcription factor cAMP-responsive element modulator (CREM) is known to play a vital role for male fertility as it has been demonstrated that male mice lacking a functional CREM gene are infertile. In testis, CREM transcriptional activity is controlled through interaction with a tissue-specific partner, activator of CREM in the testis (ACT), which confers a powerful, phosphorylation-independent activation capacity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CREM (I106) polyclonal antibody detects endogenous levels of CREM protein.

BiowMW :~ 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :cAMP-responsive element modulator; Inducible cAMP early repressor; ICER; CREM

Immunogen :Synthetic peptide, corresponding to amino acids 80-130 of Human CREM.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of CREM (I106) pAb in paraffin-embedded human liver carcinoma tissue at 1:100.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）