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Recoverin (D143) polyclonal antibody（KU）

货号: BS1983

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1983

Product Name :Recoverin (D143) polyclonal antibody（KU）

Swiss-Prot :P35243

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Recoverin is implicated in the regulation of rhodopsin kinase activity that contributes to the adaptation to background illumination in retinal photoreceptor cells. Recoverin, a Ca2+-binding photoreceptor protein, is recognized as an autoantigen of cancer-associated retinopathy (CAR), which is a rare paraneoplastic neurological syndrome characterized by the degeneration of retinal photoreceptors and associated with small-cell lung cancer. Recoverin is a heterogeneously myristoylated protein that inhibits rhodopsin kinase by inhibiting its phosphorylation. Ca2+ is required for Recoverin to bind rhodopsin kinase. In addition, the binding of Recoverin-rhodopsin kinase is weakened by autophosphorylation of the kinase and is strengthened by the presence of ADP. Upon accommodating two Ca2+ ions, Recoverin extrudes a myristoyl group and associates with the lipid bilayer membrane.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recoverin (D143) polyclonal antibody detects endogenous levels of Recoverin protein.

BiowMW :~ 26 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Recoverin; Cancer-associated retinopathy protein; Protein CAR; RCVRN; RCV1

Immunogen :Synthetic peptide, corresponding to amino acids 120-160 of Human Recoverin.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Recoverin (D143) pAb at 1:500 dilution Lane1:The Heart tissue lysate of Mouse(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:The Eye tissue lysate of Mouse(40ug) Lane4:The Eye tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of Recoverin (D143) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.