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Ptx3 (Y27) polyclonal antibody （KU）

货号: BS1965

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1965

Product Name :Ptx3 (Y27) polyclonal antibody （KU）

Swiss-Prot :P26022

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of “long pentraxins”, which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF . Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ptx3 (Y27) polyclonal antibody detects endogenous levels of Ptx3 protein.

BiowMW :~ 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14; TNFAIP5; TSG14; PTX3

Immunogen :Synthetic peptide, corresponding to the N-terminal of Human Ptx3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Ptx3 (Y27) polyclonal antibody at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:786-O whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:The Brain tissue lysate of Rat(40ug) Lane5:The Brain tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of Ptx3 (Y27) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model

JournalJournal of Diabetes Research

ApplicationIHC,WB

IF2.965

SpeciesRat

PMID29725602