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Myf-6 (R150) polyclonal antibody（KU）

货号: BS1956

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1956

Product Name :Myf-6 (R150) polyclonal antibody（KU）

Swiss-Prot :P23409

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Myf-6 (R150) polyclonal antibody detects endogenous levels of Myf-6 protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Myogenic factor 6; Myf-6; Class C basic helix-loop-helix protein 4; bHLHc4; Muscle-specific regulatory factor 4; MYF6; BHLHC4; MRF4

Immunogen :Synthetic peptide, corresponding to amino acids 120-170 of Human Myf-6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Myf-6 (R150) pAb at 1:1000 dilution Lane1:THP-1 whole cell lysate(40ug) Lane2:MG63 whole cell lysate(20ug) Lane3:PC3 whole cell lysate(10ug) Lane4:H9C2 whole cell lysate(40ug) Lane5:SP2/0 whole cell lysate(20ug)

Immunohistochemistry (IHC) analyzes of Myf-6 (R150) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo

JournalEuropean Journal Of Pharmaceutical Sciences

ApplicationWB

IF3.532

SpeciesHuman

PMID31518680