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TCF-4/12 (S616) polyclonal antibody（KU）

货号: BS1934

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1934

Product Name :TCF-4/12 (S616) polyclonal antibody（KU）

Swiss-Prot :P15884/Q99081

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TCF-4/12 (S616) polyclonal antibody detects endogenous levels of TCF-4, and also detects TCF-12 protein.

BiowMW :~ 60, 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Transcription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2; TCF4; BHLHB19; ITF2; SEF2; Transcription factor 12; TCF-12; Class B basic helix-loop-helix protein 20; bHLHb20; DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4; TCF12; BHLHB20; HEB; HTF4

Immunogen :Synthetic peptide, corresponding to amino acids 580-630 of Human TCF-4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TCF-4/12 (S616) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(20ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:Jurkat whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:PMVEC whole cell lysate(40ug) Lane6:AML-12 whole cell lysate(40ug)