Product Name :Snail1 (A242) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200
Background :The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. The Snail-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Snail1 (A242) polyclonal antibody detects endogenous levels of Snail1 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Contribution of Soluble Factors to EMT,ESC Pluripotency and Differentiation Signaling Pathway,
Alternative Name :Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna; SNAI1; SNAH; SNAI 1; Snail 1; Snail-1
Immunogen :Synthetic phosphopeptide derived from human Snail1 around the phosphorylation site of Serine 246.
Modification :Unmodification
