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LKB1 (R425) polyclonal antibody（KU）

货号: BS1785

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1785

Product Name :LKB1 (R425) polyclonal antibody（KU）

Swiss-Prot :Q15831

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LKB1 (R425) polyclonal antibody detects endogenous levels of LKB1 protein.

BiowMW :~ 48, 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Translational Contral elF4 and p70 S6 Kinase,Glutamine Metabolism,AMPK Signaling Pathway,MTOR signaling,

Alternative Name :Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19; STK11; LKB1; PJS

Immunogen :Synthetic peptide, corresponding to amino acids 396-442 of Human LKB1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of LKB1 (R425) pAb at 1:1000 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:PMVEC whole cell lysate(40ug) Lane4:The Testis tissue lysate of Mouse (40ug) Lane5:EC9706 whole cell lysate(40ug) Lane6:H1792 whole cell lysate(40ug) Lane7:SK-OVCAR3 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of LKB1 (R425) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Genistein accelerates glucose catabolism via activation the GPER-mediated cAMP/PKA-AMPK signaling pathway in broiler chickens

JournalLIFE SCIENCES

ApplicationWB

IF5.037

SpeciesChicken

PMID35640778