Product Name :Rho A (R182) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1 (A and B), Rap 2, R-Ras and Ral (A and B), exhibit approximately 50% amino acid homology to Ras. The three mammalian Rho proteins (A, B and C) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Rho A (R182) polyclonal antibody detects endogenous levels of Rho A protein
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Actin Dynamics,Regulation of Microtubule Dynamics,Adherens Junction signaling,B cell receptor signaling,
Alternative Name :Transforming protein RhoA; Rho cDNA clone 12; h12; RHOA; ARH12; ARHA; RHO12
Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human Rho A.
Modification :Unmodification
