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VDR (N204) polyclonal antibody（KU）

货号: BS1774

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1774

Product Name :VDR (N204) polyclonal antibody（KU）

Swiss-Prot :P11473

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VDR (N204) polyclonal antibody detects endogenous levels of VDR protein

BiowMW :~ 43, 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,

Alternative Name :Vitamin D3 receptor; VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1

Immunogen :Synthetic peptide, corresponding to amino acids 161-210 of Human VDR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of VDR (N204) pAb at 1:500 dilution Lane1:K562 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:3T3-L1 whole cell lysate(40ug) Lane4:The Kidney tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of VDR (N204) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Western blot (WB) analysis of VDR pAb at 1:1000 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug)