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NFATc4 (N670) polyclonal antibody（KU）

货号: BS1762

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1762

Product Name :NFATc4 (N670) polyclonal antibody（KU）

Swiss-Prot :Q14934

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :NFATc4 (nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4) is a member of the nuclear factors of activated T cells DNA-binding transcription complex that influences cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues in the NFAT homology domain of NFATc4.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NFATc4 (N670) polyclonal antibody detects endogenous levels of NFATc4 protein.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :AMPK Signaling Pathway,

Alternative Name :Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3

Immunogen :Synthetic peptide, corresponding to amino acids 635-689 of Human NFATc4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of NFATc4 (N670) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:A2780 whole cell lysate(40ug) Lane4:H1792 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of NFATc4 (N670) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells

JournalScientific Reports

ApplicationWB,IF

IF4.011

SpeciesRat

PMID28729555
miR‑155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF1.785

SpeciesRat

PMID27588076