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KSR (R386) polyclonal antibody（KU）

货号: BS1707

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1707

Product Name :KSR (R386) polyclonal antibody（KU）

Swiss-Prot :Q8IVT5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 has intrinsic kinase activity towards serine/threonine residues and is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFb-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFb stimulation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :KSR (R386) polyclonal antibody detects endogenous levels of KSR protein.

BiowMW :~ 115 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Kinase suppressor of Ras 1; KSR1; KSR

Immunogen :Synthetic peptide, corresponding to amino acids 350-402 of Human KSR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of KSR (R386) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:BV2 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of KSR (R386) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.