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TPH1 (K54) polyclonal antibody（KU）

货号: BS1698

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1698

Product Name :TPH1 (K54) polyclonal antibody（KU）

Swiss-Prot :P17752

Host :Rabbit

Reactivity :Human

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TPH1 (K54) polyclonal antibody detects endogenous levels of TPH1 protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; TPH1; TPH; TPRH; TRPH

Immunogen :Synthetic peptide, corresponding to amino acids 20-70 of Human TPH1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TPH1 (K54) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of TPH1 (K54) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.