Product Name :PC-PLD1 (K556) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Activation of phosphatidylcholine-specific phospholipase D (PC-PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA). Insulin activates the PLD-dependent hydrolysis of PC in plasma membranes of adipocytes by a mechanism that may involve wortmannin-sensitive phosphatidylinositol 3-kinase. In addition to the transient activation by growth factors stimulation, PC-PLD is constitutively activated in some of the Src- and Ras-transformed cells. PC-PLD is one of the target enzymes of ischemia; its decrease may cause a perturbation of PC hydrolysis and/or disorders of intracellular signal transduction or choline metabolism for acetylcholine formation in the brain.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PLD1 (K556) polyclonal antibody detects endogenous levels of PLD1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1; PLD1
Immunogen :Synthetic peptide, corresponding to amino acids 524-573 of Human PC-PLD1.
Modification :Unmodification
