产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

COXIII polyclonal antibody

货号: BS1674

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1674

Product Name :COXIII polyclonal antibody

Swiss-Prot :Q7JCX7

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Cytochrome c oxidase subunit III, COX3 (also designated COIII, MTCO3 or oxidative phosphorylation (OxPhos) Complex IV, subunit III) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides; COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded. Apoptosis in mammalian cells may be triggered by inhibition of mitochondrial COX. Specifically, reduction of COX3 has been associated with apoptosis and studies have shown that overexpression of COX3 results in a reduction of signals associated with apoptosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :COXIII polyclonal antibody detects endogenous levels of COXIII protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cytochrome c oxidase subunit 3; Cytochrome c oxidase subunit III; Cytochrome c oxidase sununit III; Cytochrome oxidase sununit 3; mt-Co3; Co3; COIII; COX3; COXIII

Immunogen :A synthetic peptide corresponding to amino acids 57-71 of Mouse COXIII .

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of COXIII polyclonal antibody at 1:1000 dilution Lane1:HepG-2 whole cell lysate(50μg) Lane2:A549 whole cell lysate(57μg) Lane3:The muscle tissue lysate of Mouse (33μg)