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Crystallin-αB (L55) polyclonal antibody

货号: BS1626

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1626

Product Name :Crystallin-αB (L55) polyclonal antibody

Swiss-Prot :P02511

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :α-crystallins consist of three gene products, αA, αB and αC-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens. Defects in this gene cause autosomal dominant congenital cataracts (ADCC). The human αB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Crystallin-αB (L55) polyclonal antibody detects endogenous levels of Crystallin-αB protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component; CRYAB; CRYA2; αB-Crystallin

Immunogen :Synthetic peptide, corresponding to amino acids 21-70 of Human Crystallin-αB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Crystallin-αB (L55) pAb at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:PMVEC whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Crystallin-αB (L55) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms

JournalBiochemical And Biophysical Research Communications

ApplicationWB

IF3.575

SpeciesHuman

PMID30392915