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XIAP (G81) polyclonal antibody（KU）

货号: BS1609

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1609

Product Name :XIAP (G81) polyclonal antibody（KU）

Swiss-Prot :P98170

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The human X chromosome linked Inhibitor of Apoptosis Protein (XIAP) is a major member of the inhibitor of apoptosis (IAP) family. XIAP functions by direct binding and inhibition of several caspases, including Caspase 3, Caspase 7 and Caspase 9. During apoptosis XIAP is specifically cleaved by Caspase 3 and partially loses its function. In addition to blocking the apoptosis signaling pathway, XIAP can also bind several other proteins in the bone morphogenetic protein (BMP) signaling pathway and act as a coupler between the membrane BMP receptor and the TAB1 TAK1 complex by binding to these proteins.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :XIAP (G81) polyclonal antibody detects endogenous levels of XIAP protein.

BiowMW :~ 57 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Mitochondrial Control of Apoptosis,Death Receptor Signaling,

Alternative Name :E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP; XIAP; API3; BIRC4; IAP3

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human XIAP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of XIAP (G81) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:Hela treated with H2O2 (100nmol/ml, 25min, phostop) whole cell lysate (40ug) Lane3:Hela treated with H2O2 (100nmol/ml, 25min, λ-ppase) whole cell lysate (40ug)

Immunohistochemistry (IHC) analyzes of XIAP (G81) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Down‐regulation of Notch receptor signaling pathway induces caspase‐dependent and caspase‐independent apoptosis in lung squamous cell carcinoma cells

JournalApmis

ApplicationWB

IF2.225

SpeciesHuman

PMID22583356