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WAVE1 (I119) polyclonal antibody（KU）

货号: BS1608

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1608

Product Name :WAVE1 (I119) polyclonal antibody（KU）

Swiss-Prot :Q92558

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :WAVE1 (I119) polyclonal antibody detects endogenous levels of WAVE1 protein.

BiowMW :~ 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1; WASF1; KIAA0269; SCAR1; WAVE1

Immunogen :Synthetic peptide, corresponding to amino acids 88-132 of Human WAVE1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of WAVE1 (I119) pAb at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:The Brain tissue lysate of Rat(40ug) Lane3:The Brain tissue lysate of Mouse(40ug) Lane4:Hela whole cell lysate(40ug) Lane5:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of WAVE1 (I119) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.