Product Name :WASP (E284) polyclonal antibody
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome at Xp11.23. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a 53 kDa proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :WASP (E284) polyclonal antibody detects endogenous levels of WASP protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Actin Dynamics,Contribution of ECM and Cytoskeletal Factors to EMT,Adherens Junction signaling,
Alternative Name :IMD2;
SCNX;
THC;
THC1;
Thrombocytopenia 1 (X linked);
U42471;
Was;
WASp;
WASP;
Wiskott Aldrich syndrome (eczema thrombocytopenia);
Wiskott Aldrich syndrome protein;
Wiskott-Aldrich syndrome protein;
Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human WASP.
Modification :Unmodification
