产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Tuberin (L1456) polyclonal antibody（KU）

货号: BS1605

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1605

Product Name :Tuberin (L1456) polyclonal antibody（KU）

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IF

Application_all :WB: 1:5000~1:20000 IF: 1:50~1:200

Background :Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95%

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tuberin (L1456) polyclonal antibody detects endogenous levels of Tuberin protein.

BiowMW :~ 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein

Immunogen :Synthetic peptide, corresponding to Human Tuberin.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Tuberin (L1456) polyclonal antibody at 1:2000 dilution Lane1:THP-1 whole cell lysate(40ug) Lane2:K562 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug)

Immunofluorescence analysis of A549 cells using Tuberin antibody at dilution of 1:50.