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Tuberin (F933) polyclonal antibody（KU）

货号: BS1604

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1604

Product Name :Tuberin (F933) polyclonal antibody（KU）

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tuberin/TSC2 (F933) polyclonal antibody detects endogenous levels of Tuberin/TSC2 protein.

BiowMW :~ 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Immunogen :Synthetic peptide, corresponding to amino acids 900-950 of Human Tuberin.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Tuberin (F933) polyclonal antibody at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:MEF whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Tuberin (F933) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Immunofluorescence analysis of A549 cells using Tuberin (F933) pAb at dilution of 1:200 (40x lens).

TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

JournalCell Death And Differentiation

ApplicationWB

IF10.717

SpeciesMouse

PMID29358671