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PKC δ (G499) polyclonal antibody

货号: BS1578

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1578

Product Name :PKC δ (G499) polyclonal antibody

Swiss-Prot :Q05655

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PKC δ (G499) polyclonal antibody detects endogenous levels of PKC δ protein.

BiowMW :~ 80 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Protein Kinase C Signaling,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :Protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta; Sphingosine-dependent protein kinase-1; SDK1; PRKCD; PKCδ

Immunogen :Synthetic peptide, corresponding to amino acids 470-520 of Human PKC δ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PKC δ (G499) polyclonal antibody in extracts from MCF7 cells.

Immunohistochemistry (IHC) analyzes of PKC δ (G499) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

免疫沉淀（IP）