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PDE4D (H47) polyclonal antibody（KU）

货号: BS1572

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1572

Product Name :PDE4D (H47) polyclonal antibody（KU）

Swiss-Prot :Q08499

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PDE4D (H47) polyclonal antibody detects endogenous levels of PDE4D protein.

BiowMW :~ 91 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43; PDE4D; DPDE3

Immunogen :Synthetic peptide, corresponding to amino acids 30-70 Human PDE4D.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PDE4D (H47) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate

Immunohistochemistry (IHC) analyzes of PDE4B/C/D (H47) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.