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IRAK1 (T381) polyclonal antibody（KU）

货号: BS1541

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1541

Product Name :IRAK1 (T381) polyclonal antibody（KU）

Swiss-Prot :P51617

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IRAK1 (T381) polyclonal antibody detects endogenous levels of IRAK1 protein.

BiowMW :~ 76 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Toll-like Receptor signaling,

Alternative Name :Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK1; IRAK

Immunogen :Synthetic peptide, corresponding to amino acids 350-400 of Human IRAK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IRAK1 (T381) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:THP-1 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia

JournalInternational Immunopharmacology

ApplicationWB

IF3.361

SpeciesMouse

PMID
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SpeciesRat

PMID22698579
Mechanisms of CpG-induced CD40 expression on murine bone marrow-derived dendritic cells

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IF2.125

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PMID23244216
Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

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IF0

SpeciesMouse

PMID28977876
Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2

JournalFood & Function

ApplicationWB

IF4.171

SpeciesHuman

PMID32514515