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XRCC1 (G552) polyclonal antibody（KU）

货号: BS1493

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1493

Product Name :XRCC1 (G552) polyclonal antibody（KU）

Swiss-Prot :P18887

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :XRCC1 (G552) polyclonal antibody detects endogenous levels of XRCC1 protein.

BiowMW :~ 80 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :XRCC1; X-ray repair cross-complementing protein 1; XRCC1; XRCC1. XRCC 1. XRCC-1. X-ray cross complementing factor X ray. DNA ligase. complementation protein

Immunogen :Synthetic peptide, corresponding to amino acids 520-570 of Human XRCC1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of XRCC1 (G552) polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate

Immunohistochemistry (IHC) analyzes of XRCC1 (G552) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats

JournalInternational Journal of Nanomedicine

ApplicationWB

IF5.115

SpeciesRat

PMID32904047