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TIMP-4 (S206) polyclonal antibody（KU）

货号: BS1477

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1477

Product Name :TIMP-4 (S206) polyclonal antibody（KU）

Swiss-Prot :Q99727

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metallopro teinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TIMP4 (S206) polyclonal antibody detects endogenous levels of TIMP4 protein.

BiowMW :~ 26 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4; TIMP4

Immunogen :Synthetic peptide, corresponding to amino acids 172-220 of Human TIMP-4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TIMP-4 (S206) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:The Heart tissue lysate of Rat(40ug) Lane4:The Heart tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of TIMP-4 (S206) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

CD133 Affects the Invasive Ability of HCT116 Cells by Regulating TIMP-2

JournalAmerican Journal Of Pathology

ApplicationWB

IF3.762

SpeciesHuman

PMID
Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- and PI3K/AKT Pathways

JournalEvidence-based Complementary and Alternative Medicine

ApplicationWB

IF2.629

SpeciesHuman

PMID33995548