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Caldesmon (S783) polyclonal antibody（KU）

货号: BS1437

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1437

Product Name :Caldesmon (S783) polyclonal antibody（KU）

Swiss-Prot :Q05682

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular and non-muscular forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. Alternative splicing of the gene encoding Caldesmon results in five isoforms. Muscular Caldesmon (isoform 1), also designated high molecular weight Caldesmon or H-Caldesmon (H-CAD), is expressed predominantly on thin filaments in smooth muscle. Non-muscular Caldesmon (isoforms 2-5), also designated low molecular weight Caldesmon or L-Caldesmon (L-CAD), is widely expressed in non-muscle tissues and cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caldesmon (S783) polyclonal antibody detects endogenous levels of Caldesmon protein.

BiowMW :70-80 kDa non-muscle 120-150 kDa smooth muscle

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Caldesmon; CDM; CALD1; CAD; CDM

Immunogen :Synthetic peptide, corresponding to amino acids 750-800 of Human Caldesmon.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Caldesmon (S783) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate(20ug) Lane2:Hela whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:MEF whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Caldesmon (S783) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.