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TH (Q25) polyclonal antibody（KU）

货号: BS1432

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1432

Product Name :TH (Q25) polyclonal antibody（KU）

Swiss-Prot :P07101

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tyrosine Hydroxylase (Q25) polyclonal antibody detects endogenous levels of Tyrosine Hydroxylase protein.

BiowMW :~ 58 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; TYH

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human TH.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TH (Q25) pAb at 1:2000 dilution Lane1:The Heart tissue lysate of Mouse(40ug) Lane2:The Heart tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of TH (Q25) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota–gut–brain axis

JournalFrontiers in Cellular and Infection Microbiology

ApplicationWB

IF6.073

SpeciesMouse

PMID36439235
Investigating the mechanisms of inflammation and immune alterations in Parkinson's disease using spatial transcriptomics techniques

JournalBRAIN RESEARCH BULLETIN

ApplicationWB

IF3.5

SpeciesMouse

PMID39306046