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SGK1 (E416) polyclonal antibody（KU）

货号: BS1422

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1422

Product Name :SGK1 (E416) polyclonal antibody（KU）

Swiss-Prot :O00141

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Serum- and glucocorticoid-regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1. SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositide-dependent protein kinase 1 (PDK1) capable of phosphorylating the activation-loop of SGK at Threonine-256.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SGK1 (E416) polyclonal antibody detects endogenous levels of SGK1 protein

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :MTOR signaling,

Alternative Name :Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serine/threonine-protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid regulated kinase; Serum/glucocorticoid-regulated kinase 1; SGK 1; SGK; SGK1; SGK1;

Immunogen :Synthetic peptide, corresponding to amino acids 391-440 of Human SGK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SGK1 (E416) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:H1792 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of SGK1 (E416) pAb in paraffin-embedded human breast carcinoma tissue.